6,7-Dichloroindole-2,3-dione 3-oxime
3-Oxime-6,7-dichloro-1H-indole-2,3-dione
CAS: 18711-16-5
Molecular Formula: C8H4Cl2N2O2
6,7-Dichloroindole-2,3-dione 3-oxime - Names and Identifiers
6,7-Dichloroindole-2,3-dione 3-oxime - Physico-chemical Properties
| Molecular Formula | C8H4Cl2N2O2 |
| Molar Mass | 231.04 |
| Melting Point | 190-192℃ |
| Solubility | DMSO: ~22mg/mL |
| Appearance | solid |
| Color | yellow |
| Storage Condition | 2-8°C |
| MDL | MFCD06798346 |
| Physical and Chemical Properties | Solubility: DMSO: ~ 22 mg/mL storage condition: 2-8 ℃ WGK Germany:2 |
| Use | NS309 |
| In vitro study | NS309 (40 nM) activates both hSK3 and hIK channels, with the largest effect on hIK channels (8.5-fold increase in current compares to 1.9-fold increase in current for hSK3 channels). NS309 (10 μM) significantly increases the whole cell SK currents and hyperpolarized detrusor smooth muscle (DSM) cells resting membrane potential. NS309 inhibits the spontaneous phasic contraction amplitude, force, frequency, duration and tone of isolated DSM strips in a concentration-dependent manner. |
| In vivo study | NS309 (2 mg/kg; i.p.) protects against SCI/R in rabbits. Animal Model: Adult New Zealand white rabbits (2.5-3.0 kg) Dosage: 2 mg/kg Administration: Intraperitoneal injection Result: Significantly improved neurological outcome of SCI/R challenged rabbits. |
6,7-Dichloroindole-2,3-dione 3-oxime - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 2 |
6,7-Dichloroindole-2,3-dione 3-oxime - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.328 ml | 21.641 ml | 43.283 ml |
| 5 mM | 0.866 ml | 4.328 ml | 8.657 ml |
| 10 mM | 0.433 ml | 2.164 ml | 4.328 ml |
| 5 mM | 0.087 ml | 0.433 ml | 0.866 ml |
Last Update：2024-01-02 23:10:35
6,7-Dichloroindole-2,3-dione 3-oxime - Reference Information
| Biological activity | NS309 is an effective and selective calcium-dependent potassium channel SK/IK (Ca2 -activated SK/IK potassium channels) activator, But there is no activity on the BK channel. |
| target | EC50: 0.62 µM (SK2), 0.3 μM (SK3), 20 nm (K Ca 3.1/SK4), 600 nm (K Ca 2/SK channels), 10 nm (hIK) |
| in vitro study | NS309 (40 nM) activates both hSK3 and hIK channels, with the largest effect on hIK channels (8.5-fold increase in current compares to 1.9-fold increase in current for hSK3 channels). NS309 (10 μ M) significantly increases the whole cell SK currents and hyperpolarized detrusor smooth muscle (DSM) cells resting membrane potential. NS309 inhibits the spontaneous phasic contraction amplitude, force, frequency, duration and tone of isolated DSM strips in a concentration-dependent banner. |
| in vivo study | NS309 (2 mg/kg; I. p.) protects against SCI/R in rabbits. Animal Model: Adult New Zealand White rabbits (2.5-3.0kg) Dosage: 2 mg/kg Administration: Intraperitoneal injection Result: significantly improved neurological outcome of SCI/R challenged rabbits. |
| Animal Model: | Adult New Zealand white rabbits (2.5-3.0 kg) |
| Dosage: | 2 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Significantly improved neurological outcome of SCI/R challenged rabbits. |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: NS309 Visit Supplier Webpage Request for quotationCAS: 18711-16-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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